What antibiotics can cause neutropenia?
The drugs most commonly associated with neutropenia are antibiotics (particularly beta-lactam and trimethoprim-sulfamethoxasole) as well as antithyroid drugs, antiplatelet agents, nonsteroidal anti-inflammatory agents, and noramidopyrin (3).
What medications cause low neutrophils?
Hypoglycemic agents include chlorpropamide and tolbutamide. Antimalarial drugs include amodiaquine, dapsone, hydroxychloroquine, pyrimethamine, and quinine….They include the following:
- Phenothiazine.
- Antithyroid drugs (thiouracil and propylthiouracil)
- Aminopyrine.
- Chloramphenicol.
- Sulfonamides.
Can neutropenia turn into leukemia?
Prolonged use of G-CSF in congenital neutropenias has been associated with development of pre-leukemia or leukemia, but this complication is extremely rare in cyclic neutropenia and has not been reported in autoimmune or idiopathic neutropenias.
How do you know if you have agranulocytosis?
Having very low levels of granulocytes in the blood can lead to serious or life-threatening infections. Signs and symptoms of agranulocytosis include fever, chills, weakness, sore throat, sores in the mouth or throat, bleeding gums, bone pain, low blood pressure, fast heartbeat, and trouble breathing.
What is the most severe risk for a patient with agranulocytosis?
Agranulocytosis can cause severe problems in people who have other health conditions, such as kidney disease, heart disease or breathing problems. Untreated, agranulocytosis leads to severe infection and death. The risk of infection increases the longer the neutrophil count remains dangerously low.
Does doxycycline cause neutropenia?
Among tetracycline antibiotics, doxycycline is among the least likely to cause neutropenia. Severe neutropenia should only be attributed to doxycycline after a broad differential is considered.
What medication increases neutrophils?
GCSFs, such as Neupogen (filgrastim, Amgen), Granix (tbo-filgrastim, Cephalon, Inc.), and Zarxio (filgrastim-sndz, Sandoz), stimulate and promote the maturation and activation of neutrophils. This class of drugs can also enhance the exodus of mature neutrophils trapped within the bone marrow.
Does neutropenia cause fatigue?
Neutropenia symptoms include: feeling sick (nausea) extreme tiredness (fatigue) infections that go on for a long time or keep coming back.