Is THYMOGLOBULIN an immunosuppressant?
Thymoglobulin was the first commercial rabbit-derived ATG to be introduced in Europe and the US in the 1980s. Due to its demonstrated efficacy as an immunosuppressive agent, it remains a commonly used ATG for induction therapy and treatment of other associated conditions, such as graft-vs.
Does THYMOGLOBULIN increase blood pressure?
Treatment-emergent thrombocytopenia was reported in 30 (37%) of patients following THYMOGLOBULIN infusion and in 36 (44%) of patients following Active Comparator infusion….
| Adverse Reaction | THYMOGLOBULIN (N=82) | Active Comparator* (N=81) |
|---|---|---|
| Hypotension (decreased blood pressure) | 8 (10%) | 2 (3%) |
What is THYMOGLOBULIN used for?
Background. Thymoglobulin (Thymoglobulin®; Genzyme, Cambridge, Mass., USA) is a purified polyclonal immunoglobulin used for prevention and treatment of acute rejection (AR) following renal transplantation. Thymoglobulin is mostly used for treating vascular, steroid-resistant and antibody-mediated rejection.
How does ATG decrease the immune response?
ATG may kill the targeted immune cells by inducing apoptosis, complement-mediated or NK cell-mediated lysis (16–18).
How long does effect of Thymoglobulin last?
2.1 Dosing Information The usual duration of administration is 4 to 7 days. The recommended dosage of THYMOGLOBULIN for treatment of acute rejection in patients receiving a kidney transplant is 1.5 mg/kg of body weight administered daily for 7 to 14 days.
What are the side effects of Thymoglobulin?
Nausea, fever, chills, diarrhea, dizziness, headache, or tiredness may occur. Redness, pain, or swelling at the injection site may also occur. If any of these effects persist or worsen, tell your doctor promptly. People using this medication may have serious side effects.
What are the side effects of anti rejection drugs?
Most side effects are dose-related and may decrease or subside as the dose is adjusted:
- Headache.
- Nausea.
- Trembling or shaking of hands.
- Excessive hair growth.
- High blood pressure.
- Swollen or bleeding gums.
- Increased risk for infections.
- Abnormal kidney function.
How long does ATG treatment last?
If it works, ATG usually stops the need for blood transfusions within 3 months. Full success can take at least 9 months. Some patients may respond initially, but may later relapse and need another treatment.
How is thymoglobulin made?
Thymoglobulin is made by taking donated human white blood cells (T-lymphocytes) and injecting them into a rabbit. The rabbit’s blood makes its own antibodies (a blood protein) against these T-lymphocytes. These antibodies are then taken from the rabbit’s blood and made into Thymoglobulin.
Does tacrolimus weaken your immune system?
Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ. Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body’s ability to fight infections.