What does high TSH mean in a newborn?
If your baby’s newborn screening result showed very high TSH, he or she probably has primary congenital hypothyroidism. The newborn screening test will be repeated and additional tests may also be done to help the doctors figure out if your baby has primary congenital hypothyroidism.
What is euthyroid Hypothyroxinemia?
Euthyroid hyperthyroxinemia is defined as a condition in which the serum total thyroxine (T4) and triiodothyronine (T3) concentrations are increased, but the thyroid-stimulating hormone (TSH) concentration is normal and there are no clinical signs or symptoms of thyroid dysfunction.
What is the drug of choice for newborns with congenital hypothyroidism?
Recommended starting dose of levothyroxine for congenital hypothyroidism is 10 to 15 μg/kg/day. Newborns with elevated TSH should be treated empirically with thyroid hormone replacement until they are aged 2 years to eliminate any possibility of permanent cognitive deficits caused by hypothyroidism.
What causes congenital hypothyroidism in newborns?
The most common cause worldwide is a shortage of iodine in the diet of the mother and the affected infant. Iodine is essential for the production of thyroid hormones. Genetic causes account for about 15 to 20 percent of cases of congenital hypothyroidism.
What is transient hypothyroidism?
Abstract: Transient congenital hypothyroidism (CH) refers to a temporary deficiency of thyroid hormone identified after birth, with low thyroxine (T4) and elevated thyrotropin (TSH), which later recovers to improved thyroxine production, typically in first few months of infancy.
What is the normal range of TSH in newborn baby?
Results should be interpreted using age-appropriate normative values (the TSH reference range at two to six weeks of age, the most common period of retesting, typically is 1.7 to 9.1 mU per L). Approximately 10 percent of infants with confirmed congenital hypothyroidism have TSH values between 20 and 40 mU per L.
What is isolated Hypothyroxinemia?
Isolated hypothyroxinemia is a condition in pregnancy where the T4 levels in the mother are low but the TSH levels are normal. This does not lead to hypothyroidism in the mother and eventually resolves. The cause of isolated hypothyroxinemia is unknown.
Is Euthyroidism a problem?
It is not a true syndrome, and transient alterations in the hypothalamic-pituitary-thyroid axis are present in about 75 percent of hospitalized patients. This condition is often is seen in patients with severe critical illness, deprivation of calories, and following major surgeries.
How do you manage neonatal hypothyroidism?
The mainstay in the treatment of congenital hypothyroidism is early diagnosis and thyroid hormone replacement. Optimal care includes diagnosis before age 10-13 days and normalization of thyroid hormone blood levels by age 3 weeks.
Can you cure congenital hypothyroidism?
The condition occurs in about 1 in 3,000-4,000 children, is most often permanent and treatment is lifelong. Thyroid hormone is important for your baby’s brain development as well as growth, therefore, untreated congenital hypothyroidism can lead to intellectual disabilities and growth failure.
