How do I administer RiaSTAP?
Administer RIASTAP at room temperature by slow intravenous injection at a rate not exceeding 5 mL per minute. RIASTAP is available as a single-dose vial containing 900 mg to 1300 mg lyophilized fibrinogen concentrate powder for reconstitution with 50 mL of Sterile Water for Injection.
Is RiaSTAP a blood product?
RiaSTAP is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.
How much does fibrinogen concentrate cost?
In terms of current costs in the US, the two options at these doses would cost ~$3000 (fibrinogen concentrate) and $1300 (CRYO).
When do you give fibrinogen?
Indications for fibrinogen replacement therapy include the following conditions: Congenital disorders: Patients with congenital afibrinogenemia, hypofibrinogenemia, or dysfibrinogenemia, who present with clinically significant bleeding should be given fibrinogen concentrate to raise levels to 100-150mg/dL.
How do I reconstitute RiaSTAP?
Ensure that the diluent and RiaSTAP® product vial(s) are at room temperature. If product and diluent are not at room temperature prior to reconstitution, product may take longer to dissolve. 2. RiaSTAP® is reconstituted with 50 mL sterile water for injection (diluent).
What is RiaSTAP used for?
RiaSTAP is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency (CFD), including afibrinogenemia and hypofibrinogenemia.
Which blood product has the most fibrinogen?
Although cryoprecipitate contains a higher concentration of fibrinogen than FFP, usually around 15 g/L, it shares many of the disadvantages of FFP (see Table I) as its fibrinogen concentration is not standardised and blood group matching is needed prior to transfusion.
How is fibrinogen concentrate made?
A plasma-derived fibrinogen concentrate (RiaSTAP®, CSL Behring) is FDA-approved for the treatment of acute bleeding episodes in patients with congenital afibrinogenemia and hypofibrinogenemia. The product is prepared by purification from cryoprecipitate and undergoes viral reduction and inactivation processes.
Can you transfuse fibrinogen?
Fibrinogen supplementation can be provided by transfusion of fresh-frozen plasma (FFP), cryoprecipitate and fibrinogen concentrate5,6.
How fast do you transfuse cryoprecipitate?
The typical infusion rate is 10-20mL/ kg/hr (30-60 min per five pool unit).
How fast can you give fibrinogen?
Congenital fibrinogen deficiency: Administer the entire dose at a maximum rate of 5 mL per minute (approximately 100 mg per minute; 1 reconstituted vial over 10 minutes).
How do you dissolve human fibrinogen?
The optimal way to solubilize fibrinogen is to layer it on top of warm (37 °C) saline; fibrinogen will not dissolve in water. The saline concentration can be in the range of 0.85–0.9%. The fibrinogen-saline solution can be gently agitated, but it must not be vortexed.