What does CB2 agonist do?
CB2 agonists modulate peripheral neuroinflammation [97] Stimulation with lipopolysaccharide enhanced the expression of CB2 receptors and the production of pro- and anti-inflammatory factors in human keratinocytes and fibroblasts.
What are CB1 and CB2 receptors responsible for?
The CB1 receptor mediates most of the psychoactive effects of cannabinoids, whereas the CB2 receptor is principally involved in anti-inflammatory and immunosuppressive actions.
What do CB2 receptors regulate?
It is mainly expressed in immune tissues, highlighting the possibility that the endocannabinoid system has an immunomodulatory role. In this respect, the CB2 receptor was shown to modulate immune cell functions, both in cellulo and in animal models of inflammatory diseases.
What activates the CB2 receptor?
The cannabinoid receptors CB1 and CB2 are activated by three major groups of ligands: endocannabinoids, plant cannabinoids, and synthetic cannabinoids.
What happens when CB2 receptors are activated?
In glial cells, the activation of CB2 receptors inhibits the release of several inflammatory mediators, including nitric oxide and pro-inflammatory cytokines such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, and IL-6, and increases the release of anti-inflammatory cytokines such as IL-10 and IL-1 receptor …
What is the CB1 receptor responsible for?
CB1 receptors are expressed most densely in the central nervous system and are largely responsible for mediating the effects of cannabinoid binding in the brain.
What is CB2 used for?
In contrast, CB2 is mainly expressed in the immune system (to a lesser extent in the central nervous system) and does not create a psychotropic reaction. As a result, CB2 is emerging as a potential therapeutic target for treating inflammatory and neuropathic pain.
Is CBD a CB2 agonist?
The ability of cannabidiol to behave as a CB2 receptor inverse agonist may contribute to its documented anti-inflammatory properties.
What is a CB1 agonist?
Cannabinoid CB1 receptor agonists, including delta-9-tetra-hydrocannabinol (THC), have a wide variety of behavioral effects, including actions on motor control [1–3], pain [1,3], and cognitive function [4–7]. These drugs also have been reported to exert effects upon processes related to food intake.
Where are CB1 receptors mainly found in humans?
The CB1 receptors are primarily located on nerve cells in the brain, spinal cord, but they are also found in some peripheral organs and tissues such as the spleen, white blood cells, endocrine gland and parts of the reproductive, gastrointestinal and urinary tracts.
