What is category D for drugs during pregnancy?
Category D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
What class is taclonex?
Taclonex belongs to a class of drugs called Antipsoriatics, Topical.
Is taclonex a corticosteroid?
Taclonex (calcipotriene and betamethasone dipropionate) Ointment is a combination of a form of vitamin D and a topical (for the skin) corticosteroid used to treat psoriasis vulgaris.
What is taclonex drug used for?
This medication is used to treat psoriasis. It helps to reduce the redness, thickening, and scaling of the skin that occurs with this condition. Healthy skin lowers your risk for infection and protects you against the environment.
Which drug is not teratogenic?
Examples of non-teratogenic agents: spermicides, acetaminophen, prenatal vitamins, using a microwave to cook food. A non-teratogenic agent is one which does not cause birth defects.
Is Taclonex safe for pregnant or breastfeeding women?
Taclonex® Topical Suspension contains calcipotriene that has been shown to be fetotoxic and betamethasone dipropionate that has been shown to be teratogenic in animals when given systemically. There are no adequate and well-controlled studies in pregnant women.
What is the clinical pharmacology of Taclonex?
Taclonex – Clinical Pharmacology 1 Mechanism of Action. Taclonex ® Ointment combines the pharmacological effects of calcipotriene hydrate as a synthetic vitamin D 3 analogue and betamethasone dipropionate as a synthetic corticosteroid. 2 Pharmacodynamics. 3 Pharmacokinetics.
Is Taclonex teratogenic?
Taclonex ® Ointment contains calcipotriene that has been shown to be fetotoxic and betamethasone dipropionate that has been shown to be teratogenic in animals when given systemically. Teratogenicity studies with calcipotriene were performed by the oral route in rats and rabbits.
What is the prevalence of Taclonex in the US?
Taclonex ® Ointment was studied primarily in placebo- and active-controlled trials (N = 1176, and N = 1272, respectively). The population was 15-97 years old, 61% males and 39% females, mostly white (97%) and had a baseline disease severity ranging from mild to very severe.
